UMP kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.4 Phosphotransferases with a phosphate group as acceptor > 2.7.4.22 UMP kinase
UMP kinase is the prokaryotic pyrimidine-salvage/de novo UTP-biosynthesis kinase. It is strictly specific for UMP and phosphorylates it to UDP, releasing ADP; it is feedback-inhibited by UTP and activated by GTP. Unlike eukaryotes that use dual-specificity UMP/CMP kinase EC 2.7.4.14, prokaryotes use this enzyme. It occurs in viruses and cellular organisms.
UMP kinase is the prokaryotic pyrimidine-salvage/de novo UTP-biosynthesis kinase. It is strictly specific for UMP and phosphorylates it to UDP, releasing ADP; it is feedback-inhibited by UTP and activated by GTP. Unlike eukaryotes that use dual-specificity UMP/CMP kinase EC 2.7.4.14, prokaryotes use this enzyme. It occurs in viruses and cellular organisms.
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