Xanthine dehydrogenase
Definition:
EC Tree > 1 Oxidoreductases > 1.17 Acting on CH or CH2 groups > 1.17.1 With NAD+ or NADP+ as acceptor > 1.17.1.4 xanthine dehydrogenase
Xanthine dehydrogenase is a eukaryotic [2Fe-2S]/FAD/molybdenum enzyme that oxidizes xanthine/hypoxanthine (and other purines/aldehydes) with NAD+ to urate; the mammalian enzyme reversibly converts to O2-dependent xanthine oxidase (EC 1.17.3.2) by disulfide rearrangement or proteolysis.
Xanthine dehydrogenase is a eukaryotic [2Fe-2S]/FAD/molybdenum enzyme that oxidizes xanthine/hypoxanthine (and other purines/aldehydes) with NAD+ to urate; the mammalian enzyme reversibly converts to O2-dependent xanthine oxidase (EC 1.17.3.2) by disulfide rearrangement or proteolysis.
References:
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