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Cat. No.: HY-16108

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BMS-187745

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle.

For research use only. We do not sell to patients.

CAS No.: 157126-18-6
Formula: C₁₆H₁₉O₇PS
Molecular Weight:386.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-187745 Chemical Structure

CAS No.: 157126-18-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle^[1].

IC₅₀ & Target

Squalene Synthase^[1]

In Vitro

Protein/Amino Acid MetabolismLipid Metabolism

Protein/Amino Acid Metabolism

BMS-187745 (10-2000 μM; 48 h) does not induce significant myotoxicity (changes in protein synthesis, total protein or LDH release) in primary cultures of neonatal rat skeletal muscle cells at concentrations up to 1000 μM, with only mild irreversible cytotoxicity observed at the highest tested concentration of 2000 μM^[1].

Lipid Metabolism

BMS-187745 (0.1-100 μM) potently inhibits de novo cholesterol synthesis in primary cultures of neonatal rat skeletal muscle cells, with an IC₅₀ of 6.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 157126-18-6
Molecular Weight 386.35
Formula C₁₆H₁₉O₇PS
SMILES

O(C1=CC(CCC[C@@H](P(=O)(O)O)S(=O)(=O)O)=CC=C1)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Flint OP, et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicology and applied pharmacology. 1997 Jul;145(1):91-8. [Content Brief]

[2]. Sun C Q, et al. A general synthesis of dioxolenone prodrug moieties[J]. Tetrahedron Letters, 2002, 43(7): 1161-1164.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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