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Cat. No.: HY-184880

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BMS-986144 (non-deuterated)

BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection.

For research use only. We do not sell to patients.

CAS No.: 1410114-25-8
Formula: C₄₀H₅₁F₄N₅O₉S
Molecular Weight:853.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-986144 (non-deuterated) Chemical Structure

CAS No.: 1410114-25-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Viral InfectionOthers

Viral Infection

BMS-986144 (compound 21) non-deuterated form inhibits GT-3a (S52) HCV NS3/4A protease with an IC50 of 4.8 nM, and suppresses HCV replication across pan-genotypic and drug-resistant replicon cell lines with EC50 values ranging from 0.7 nM (GT-1b) to 12 nM (GT-3a)^[1].

Others

BMS-986144 (0.002-40 μM; 0 and 30 min preincubation) non-deuterated presents attenuated time-dependent inhibitory activity toward CYP3A4^[1].
BMS-986144 non-deuterated displays in vitro cytotoxicity against Huh7 and MT2 cell lines, with CC50 values of 25 μM and 34 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1410114-25-8
Molecular Weight 853.92
Formula C₄₀H₅₁F₄N₅O₉S
SMILES

O=C(OC(C)(C)C(F)(F)F)N[C@H]1[C@H](CC)C[C@H](C)CC/C=C\[C@@]2([H])[C@](C2)(C(NS(=O)(C3(C)CC3)=O)=O)NC([C@@](C[C@@H](OC4=NC=CC5=C4C=C(F)C(OC)=C5)C6)([H])N6C1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun L Q, et al. Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Journal of Medicinal Chemistry, 2020, 63(23): 14740-14760.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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