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Cat. No.: HY-NP0239

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Bovine Thyrotropin

Bovine Thyrotropin is a pituitary glycoprotein hormone derived from cattle, with identical properties to thyroid-stimulating hormone (TSH). Bovine Thyrotropin stimulates thyroid function and is used to differentiate between primary and secondary hypothyroidism. Bovine Thyrotropin can induce increased radioactive iodine uptake in metastatic thyroid cancer lesions, and long-term administration leads to the production of neutralizing antibodies and hemagglutinating antibodies. Bovine Thyrotropin is applicable to research related to metastatic thyroid cancer.

For research use only. We do not sell to patients.

CAS No.: 9002-71-5

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Bovine Thyrotropin Chemical Structure

CAS No.: 9002-71-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Bovine thyrotropin (80-400 mU/mL; 15 min) dose-dependently stimulates adenylate cyclase in bovine thyroid plasma membranes, reaching maximal activity at 300 mU/mL, with higher concentrations causing inhibition; this stimulatory activity is completely blocked by concurrent incubation with crude hCG but not purified hCG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

CAS No. 9002-71-5
SMILES

[Bovine Thyrotropin]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Amir SM, et al. Interactions of bovine thyrotropin and human chorionic gonadotropin with adenylate cyclase in bovine thyroid membranes. Endocrine Research Communications. 1978 Jan 1;5(3):239-47.

[2]. Robbins J. Pharmacology of bovine and human thyrotropin: an historical perspective. Thyroid. 1999 May;9(5):451-3.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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