BRAF V600E/CRAF-IN-1
Based on 1 Customer Validation
BRAF V600E/CRAF-IN-1 (Compound 8b) is a potent inhibitor of BRAF V600E/CRAF. BRAF V600E/CRAF-IN-1 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-1 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- Purity : 98.32%
- CAS No.: 2499499-56-6
- Formula: C25H17F6N3O2
- Molecular Weight:505.41
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 2499499-56-6
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Appearance Solid
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Molecular Weight 505.41
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Formula C25H17F6N3O2
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Color White to off-white
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SMILES
COC1=C2C=CC(NC3=CC(NC(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)=CC=C3)=NC2=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (197.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9786 mL | 9.8930 mL | 19.7859 mL | 49.4648 mL |
| 5 mM | 0.3957 mL | 1.9786 mL | 3.9572 mL | 9.8930 mL | |
| 10 mM | 0.1979 mL | 0.9893 mL | 1.9786 mL | 4.9465 mL | |
| 15 mM | 0.1319 mL | 0.6595 mL | 1.3191 mL | 3.2977 mL | |
| 20 mM | 0.0989 mL | 0.4946 mL | 0.9893 mL | 2.4732 mL | |
| 25 mM | 0.0791 mL | 0.3957 mL | 0.7914 mL | 1.9786 mL | |
| 30 mM | 0.0660 mL | 0.3298 mL | 0.6595 mL | 1.6488 mL | |
| 40 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2366 mL | |
| 50 mM | 0.0396 mL | 0.1979 mL | 0.3957 mL | 0.9893 mL | |
| 60 mM | 0.0330 mL | 0.1649 mL | 0.3298 mL | 0.8244 mL | |
| 80 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6183 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1979 mL | 0.4946 mL |
BRAF V600E/CRAF-IN-1 Related Classifications
HY-146442 Related Classifications
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