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Cat. No.: HY-186268

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BRD4 ligand-Linker Conjugate 8

BRD4 ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that can be used in studies related to PROTAC synthesis. BRD4 ligand-Linker Conjugate 8 is applicable for the synthesis of BD-7148 (HY-186267).

For research use only. We do not sell to patients.

CAS No.: 3034180-15-6
Formula: C₂₆H₂₃F₃N₆O₃S
Molecular Weight:556.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BRD4 ligand-Linker Conjugate 8 Chemical Structure

CAS No.: 3034180-15-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Anti-cancer

BRD4 ligand-Linker Conjugate 8 can be used for the synthesis of BD-7148 (HY-186267). BD-7148 (compound 5) is a PROTAC degrader targeting BRD4, with a DC₅₀ of 0.9 nM, and inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034180-15-6
Molecular Weight 556.56
Formula C₂₆H₂₃F₃N₆O₃S
SMILES

CC(N12)=NN=C2COCC3=C1SC(C#CC4=CN(N=C4)C5CNC5)=C3CC6=CC=CC=C6.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu J, et al. Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity. Journal of medicinal chemistry. 2023 Jun 22;66(12):8222-8237. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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