c-Myc inhibitor 8
Based on 1 Customer Validation
c-Myc inhibitor 8 (compound 56) is a c-Myc inhibitor. c-Myc inhibitor 8 effectively inhibits cell viability of a variety of cancer cells. c-Myc inhibitor 8 inhibits human prostate and lung cancer growth in mouse models. c-Myc inhibitor 8 can be used for cancer research.
For research use only. We do not sell to patients.
- Purity : 99.04%
- CAS No.: 2173505-97-8
- Formula: C19H12BrClF3NO3S2
- Molecular Weight:538.79
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of KU-19-19, 253J, J82, Τ24, ΜΒΤ-2 and UM-UC-3 bladder cancer cell lines with IC50s of 0.90, 1.11, 1.46, 0.98, 1.18 and 1.25 μM, respectively[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of Α549, NCI-H460, MRC-5 and NCI-H23 hepatoma cell lines with IC50s of 1.70, 1.90, 1.24 and 1.04 μM, respectively[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of MDA-MB-231, SK-BR-3, HCC1954 and MDA-MB-468 breast cancer cell lines with IC50s of 1.45, 1.38, 1.47 and 1.64 μM, respectively[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of HL-60, U-937, Raji, Ramos (RAl), Daudi, Jurkat, MV-4-11 and MOLT-4 blood cancer cell lines with IC50s of 1.95, 1.75, 1.12, 1.86, 1.25, 1.06, 1.50 and 1.66 μM, respectively[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of ΜΙΑ PaCa-2 pancreatic cancer cell line with an IC50 of 1.37 μM[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of HCT 116, SW620, HCT-15, RKO, HCT-8 and DLD-I colorectal cancer cell lines with IC50s of 1.19, 1.91, 1.32, 1.53, 1.69 and 0.80 μM, respectively[1]. c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of U-251 MG, U-138 MG, LOX-IMVI, SK-HEP-I and OVCAR-3 cancer cell lines with IC50s of 1.17, 1.34, 1.09, 1.02 and 1.09 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2173505-97-8
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Appearance Solid
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Molecular Weight 538.79
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Formula C19H12BrClF3NO3S2
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Color White to off-white
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SMILES
O=C1C2=C(NC(S(CC3=CC=C(C=C3)SC(F)(F)F)=O)=C1C(C)=O)C(Br)=CC=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (18.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8560 mL | 9.2801 mL | 18.5601 mL | 46.4003 mL |
| 5 mM | 0.3712 mL | 1.8560 mL | 3.7120 mL | 9.2801 mL | |
| 10 mM | 0.1856 mL | 0.9280 mL | 1.8560 mL | 4.6400 mL | |
| 15 mM | 0.1237 mL | 0.6187 mL | 1.2373 mL | 3.0934 mL |
c-Myc inhibitor 8 Related Classifications
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