C16-VVVAAAEEE
C16-VVVAAAEEE is a peptide amphiphile and biodegradable nanofiber scaffold that self-assembles into a hydrogel upon calcium ion triggering, enabling delivery of Sonic hedgehog protein to corpus cavernosum smooth muscle with prolonged release and without eliciting a significant immune response. C16-VVVAAAEEE is used in research on erectile dysfunction.
For research use only. We do not sell to patients.
- CAS No.: 843663-78-5
- Formula: C55H95N9O17
- Molecular Weight:1154.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rats (postnatal day 115-120, bilateral cavernous nerve resection)[1]
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Dosage:20; 50; 100 µL (volume optimization); 50 µL (duration study); 10 mM final concentration
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Administration:Injection into corpora cavernosa; single administration
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Result:Visualized a highly brightened region of the penis at 20 µL.
Formed a gel uniformly throughout the entire penis at 50 µL.
Did not remain localized within the penis at 100 µL.
Remained localized completely in the penis when a silk tie was used.
Showed well dispersed fluorescence throughout both corpora cavernosa when injected distally.
Did not appear to reach all of the adjacent corpus cavernosum when injected proximally.
Formed a thin layer lining the sinusoidal spaces at 1 hour.
Was still abundant and clearly visible within the corpora cavernosa at 7 days.
Was observed as a nonspecific fluorescence indicating mostly degraded at 14 days.
Chemical Information
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CAS No. 843663-78-5
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Molecular Weight 1154.39
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Formula C55H95N9O17
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Sequence
C16-Val-Val-Val-Ala-Ala-Ala-Glu-Glu-Glu
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Sequence Shortening
C16-VVVAAAEEE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C16-VVVAAAEEE Related Classifications
HY-P12356 Related Classifications
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Keywords
- C16-VVVAAAEEE
- 843663-78-5
- Biochemical Assay Reagents
- Sonic hedgehog protein
- extended protein release
- self-assembling peptide amphiphile nanofiber hydrogel
- erectile dysfunction
- hydrogel
- immune response
- calcium ions
- biodegradable nanofiber scaffold
- penile corpora cavernosal smooth muscle
- peptide amphiphile
- Inhibitor
- inhibitor
- inhibit