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Cat. No.: HY-148535

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Calpain Inhibitor XI

Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders.

For research use only. We do not sell to patients.

CAS No.: 145731-49-3
Formula: C₂₆H₄₀N₄O₆
Molecular Weight:504.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Calpain Inhibitor XI Chemical Structure

CAS No.: 145731-49-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders^[1].

In Vitro

Calpain inhibitor XI (CaXI) (1 μM) can inhibit calpain-1, cathepsin-K and also modestly inhibits (∼20%) both papain and cathepsin-B^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 145731-49-3
Molecular Weight 504.62
Formula C₂₆H₄₀N₄O₆
SMILES

O=C(NC(CC(C)C)C(NC(CC)C(C(NCCCN1CCOCC1)=O)=O)=O)OCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rachel C Knopp, et al. Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. ACS Pharmacol Transl Sci. 2021 Feb 2;4(1):372-385. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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