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Cat. No.: HY-190464

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Carbonic anhydrase-IN-42

Carbonic anhydrase-IN-42 is an NSAID‑CAI hybrid molecule and an orally active and selective Carbonic anhydrase inhibitor. Carbonic anhydrase-IN-42 exhibits antimycobacterial activity against Mycobacterium marinum and attenuated Mycobacterium tuberculosis, and enhances the antimycobacterial activity of Rifampicin (HY-B0272). Carbonic anhydrase-IN-42 can be used for research on tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 2231227-18-0
Formula: C₂₄H₂₄N₂O₅S
Molecular Weight:452.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Carbonic anhydrase-IN-42 Chemical Structure

CAS No.: 2231227-18-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

hCA II

0.009 μM (Ki)

hCA I

0.077 μM (Ki)

All Carbonic Anhydrase Isoforms :

In Vitro

Bacterial Infection

Carbonic anhydrase-IN-42 (compound 12) is a potent cell-free inhibitor of Mtb β-CA2 (K_I 0.162 μM) and hCA XII (K_I 0.009 μM), with weaker activity against Mtb β-CA1 and Mtb β-CA3^[1].
Carbonic anhydrase-IN-42 (24-72 h) exhibits the strongest inhibitory effect on mycobacterial bioluminescence signals in H37Ra Mtb biofilms^[1].
Carbonic anhydrase-IN-42 (100 μM; 24-96 h) enhances the activity of Rifampicin (HY-B0272) in Mmr biofilms in a CFU-based time-kill assay, but no bactericidal activity is identified for it alone^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

Carbonic anhydrase-IN-42 (compound 12) (68 mg/kg; p.o.; daily; from 4 wpi to 10 wpi endpoint) combined with Rifampicin (HY-B0272) does not reduce the Mycobacterium marinum burden in infected adult AB zebrafish in this model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2231227-18-0
Molecular Weight 452.52
Formula C₂₄H₂₄N₂O₅S
SMILES

NS(C(C=C1)=CC=C1OCCNC(C(C)C2=CC(C(C3=CC=CC=C3)=O)=CC=C2)=O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Parkkinen J, et al. First-in-class nonsteroidal anti-inflammatory drug and carbonic anhydrase inhibitor hybrid compounds as effective antimycobacterial agents. European journal of medicinal chemistry. 2026 Oct 15;316:119037.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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