1000700-26-4
1000700-26-4
Chemical Structure
ATB-343
- CAS No.: 1000700-26-4
- Formula:C28H20ClNO4S3
- Molecular Weight:566.11
IUPAC Name: 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
InChIKey: SJLZXDOBSHEDIF-UHFFFAOYSA-N
SMILES: O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC4=CC=C(C(SS5)=CC5=S)C=C4
Biological Activity: ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections[1][2].
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ATB-343 | ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections. | |||||||||||||||||||||
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References
- [1]. Li M, et al. Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2017 Sep 29;138:51-65. [Content Brief]
- [2]. Methods for treating viral infections using hydrogen sulfide (H2S) donors. United States, US20160058779 A1 2016-03-03.
