1001389-31-6
1001389-31-6
Chemical Structure
GSK1370319A
- CAS No.: 1001389-31-6
- Formula:C13H14Cl2N2O2
- Molecular Weight:301.17
IUPAC Name: (S)-N-(2,4-dichlorobenzyl)-1-methyl-5-oxopyrrolidine-2-carboxamide
InChIKey: YMNOJCVLDDTECB-NSHDSACASA-N
SMILES: C(NCC1=C(Cl)C=C(Cl)C=C1)(=O)[C@H]2N(C)C(=O)CC2
Biological Activity: GSK1370319A is a human P2X7 receptor inhibitor with an IC50 of 474 nM and a Ki of 176 nM. GSK1370319A inhibits the production of IL-1β, reduces the generation of reactive oxygen species (ROS), and increases the survival rate of macrophages. GSK1370319A can be used for the research of inflammatory bowel disease[1].
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GSK1370319A | GSK1370319A is a human P2X7 receptor inhibitor with an IC50 of 474 nM and a Ki of 176 nM. GSK1370319A inhibits the production of IL-1β, reduces the generation of reactive oxygen species (ROS), and increases the survival rate of macrophages. GSK1370319A can be used for the research of inflammatory bowel disease. | |||||||||||||||||||||
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