100287-06-7
100287-06-7
Chemical Structure
4-Hydroxyphenylacetic acid-d6
- CAS No.: 100287-06-7
- Formula:C8H2D6O3
- Molecular Weight:158.18
IUPAC Name: 2-(4-hydroxyphenyl-2,3,5,6-d4)acetic-2,2-d2 acid
InChIKey: XQXPVVBIMDBYFF-NVSFMWKBSA-N
SMILES: OC(C([2H])([2H])C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O
Biological Activity: 4-Hydroxyphenylacetic acid-d6 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Hydroxyphenylacetic acid-d6 | 99.16% | 4-Hydroxyphenylacetic acid-d6 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. | ||||||||||||||||||||
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4-Hydroxyphenylacetic acid (Standard) | 99.24% | 4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1. | ||||||||||||||||||||
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4-Hydroxyphenylacetic acid-13C | 4-Hydroxyphenylacetic acid-13C is the 13C-labeled 4-Hydroxyphenylacetic acid (HY-N1902). 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. | |||||||||||||||||||||
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4-Hydroxyphenylacetic acid-d4 | 98.75% | 4-Hydroxyphenylacetic acid-d4 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. | ||||||||||||||||||||
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4-Hydroxyphenylacetic acid-d2 | 4-Hydroxyphenylacetic acid-d2 is the deuterium labeled 4-Hydroxyphenylacetic acid (HY-N1902). 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. | |||||||||||||||||||||
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4-Hydroxyphenylacetic acid | 99.96% | 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. | ||||||||||||||||||||
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O-Toluic acid-d7 | 99.53% | O-Toluic acid-d7 is the deuterium labeled o-Toluic acid. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite. | ||||||||||||||||||||
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4-Aminophenylacetic acid | 99.26% | 4-Aminophenylacetic acid is a kind of biological materials or organic compounds that are widely used in life science research. | ||||||||||||||||||||
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p-Toluic acid-d7 | 99.72% | p-Toluic acid-d7 is the deuterium labeled p-Toluic acid. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc. | ||||||||||||||||||||
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3-Methylbenzoic acid-d7 | 3-Methylbenzoic acid-d7 is the deuterium labeled 3-Methylbenzoic acid. | |||||||||||||||||||||
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Homovanillic acid-d5 | 99.0% | Homovanillic acid-d5 (Vanilacetic acid-d5) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. | ||||||||||||||||||||
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3,4-Dihydroxybenzeneacetic acid-d5 | 98.67% | 3,4-Dihydroxybenzeneacetic acid-d5 is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine. | ||||||||||||||||||||
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3-Hydroxyphenylacetic acid (Standard) | 99.71% | 3-Hydroxyphenylacetic acid (Standard) is the analytical standard of 3-Hydroxyphenylacetic acid (HY-W001083). This product is intended for research and analytical applications. 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders. | ||||||||||||||||||||
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4-(Hydroxymethyl)phenylacetic acid | 97.0% | 4-(Hydroxymethyl)phenylacetic acid can serve as the main body of insoluble polypeptide. 4-(Hydroxymethyl)phenylacetic acid can react with DEPBT and 4-acetylaniline to form amide intermediates. 4-(Hydroxymethyl)phenylacetic acid is a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota. 4-(Hydroxymethyl)phenylacetic acid significantly inhibits 6-MP oxidation and has no significant inhibition on xanthine oxidation. | ||||||||||||||||||||
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4-Hydroxyphenylpyruvic acid (Standard) | 96.44% | 4-Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria. | ||||||||||||||||||||
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4-Chlorophenylacetic acid | 99.94% | 4-Chlorophenylacetic acid is an aromatase antagonist. 4-Chlorophenylacetic acid inhibits estrogen-induced breast tumorigenesis by blocking estrogen conversion. 4-Chlorophenylacetic acid also serves as the sole carbon and energy source for Pseudomonas sp. CBS3; it is degraded via dechlorination and aromatic ring cleavage pathways, and induces the synthesis of protocatechuate 2,3-dioxygenase. 4-Chlorophenylacetic acid can be applied to studies related to estrogen-induced breast tumors and bacterial degradation pathways. | ||||||||||||||||||||
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Desaminotyrosine (Standard) | ≥98% | Desaminotyrosine (Standard) (3-(4-Hydroxyphenyl)propionic acid (Standard)) is the analytical standard of Desaminotyrosine (HY-W015346). This product is intended for research and analytical applications. Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. | ||||||||||||||||||||
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2-Hydroxyphenylacetic acid | 98.79% | 2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, as well as a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid acts as a potential biomarker for food. 2-Hydroxyphenylacetic acid slightly induces the expression of green fluorescent protein. 2-Hydroxyphenylacetic acid is used in the research of phenylketonuria and related hyperphenylalaninemia. | ||||||||||||||||||||
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2-(4-Hydroxyphenyl)acetamide (Standard) | ≥98% | 2-(4-Hydroxyphenyl)acetamide (Standard) is the analytical standard of 2-(4-Hydroxyphenyl)acetamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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2-(Pyridin-2-yl)acetic acid-d6 hydrochloride | 2-(Pyridin-2-yl)acetic acid-d6 hydrochloride is the deuterated derivative of 2-(Pyridin-2-yl)acetic acid hydrochloride (HY-W016825). 2-(Pyridin-2-yl)acetic acid hydrochloride is a heterocyclic aromatic carboxylic acid compound. 2-(Pyridin-2-yl)acetic acid hydrochloride can be used as an organic synthesis intermediate or a metal complex. | |||||||||||||||||||||
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4-(4-Hydroxyphenyl)butanoic acid | 98.82% | 4-(4-Hydroxyphenyl)butanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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2-Carboxyphenol-d4 | 99.83% | 2-Carboxyphenol-d4 is the deuterium labeled 2-Carboxyphenol. 2-Carboxyphenol is a plant hormone and mediates host responses against microbial pathogens. | ||||||||||||||||||||
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p-Hydroxyphenylacetone | p-Hydroxyphenylacetone, a Raspberry ketone (HY-N1426) derivative, is an androgen receptor (AR) antagonist with an IC50 of 420 μM in MDA-kb2 human breast cancer cells. p-Hydroxyphenylacetone can be used for breast cancer research. | |||||||||||||||||||||
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2'-Hydroxyacetophenone-d7 | 2'-Hydroxyacetophenone-d7 (o-Hydroxyacetophenone-d7; o-Acetylphenol-d7) is the deuterium labeled 2'-Hydroxyacetophenone (HY-Y1426). 2'-Hydroxyacetophenone is found in alcoholic beverages. 2'-Hydroxyacetophenone is present in tomato, cassia, fried beef, rum, whiskey, cocoa, coffee and black tea. 2'-Hydroxyacetophenone is a flavouring ingredient. Building block in chemical synthesis. | |||||||||||||||||||||
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4-Hydroxy-3-nitrophenylacetic acid-d5 | 4-Hydroxy-3-nitrophenylacetic acid-d5 is the deuterium labeled 4-Hydroxy-3-nitrophenylacetic acid (HY-W001085). | |||||||||||||||||||||
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4-Hydroxybenzoic acid-d4 | 99.97% | 4-Hydroxybenzoic acid-d4 is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. | ||||||||||||||||||||
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