1005056-10-9
Chemical Structure
RKN5755
- CAS No.: 1005056-10-9
- Formula:C14H16O3
- Molecular Weight:232.28
InChIKey: ZMWQOEWNVDTTKC-UHFFFAOYSA-N
SMILES: OC(C1CCC2)(OC(C1)=O)C2C3=CC=CC=C3
Biological Activity: RKN5755 is a β-arrestin1 inhibitor and a selective inhibitor of activated fibroblasts. RKN5755 binds to β-arrestin1 and interferes with the cofilin signaling pathway mediated by this protein to block its function. RKN5755 not only inhibits the enhanced migratory effect of fibroblasts co-cultured with cancer cells, but also prevents the inhibitory effect of EP3 agonists on the EP2 receptor-induced elevation of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons. RKN5755 is widely used in research on related diseases such as cancer metastasis and pain[1][2].
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RKN5755 | RKN5755 is a β-arrestin1 inhibitor and a selective inhibitor of activated fibroblasts. RKN5755 binds to β-arrestin1 and interferes with the cofilin signaling pathway mediated by this protein to block its function. RKN5755 not only inhibits the enhanced migratory effect of fibroblasts co-cultured with cancer cells, but also prevents the inhibitory effect of EP3 agonists on the EP2 receptor-induced elevation of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons. RKN5755 is widely used in research on related diseases such as cancer metastasis and pain. | |||||||||||||||||||||
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References
- [1]. Suvarna K, et al. Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells. Cancer medicine. 2018 Mar;7(3):883-893. [Content Brief]
- [2]. König C, et al. Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2. British journal of pharmacology. 2023 Feb;180(4):441-458.
