1005201-24-0
1005201-24-0
Chemical Structure
TCS2002
- CAS No.: 1005201-24-0
- Formula:C18H14N2O3S
- Molecular Weight:338.38
IUPAC Name: 2-methyl-5-(3-(4-(methylsulfinyl)phenyl)benzofuran-5-yl)-1,3,4-oxadiazole
InChIKey: RCKYSTKYIVULEK-UHFFFAOYSA-N
SMILES: O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23
Biological Activity: TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TCS2002 | 99.80% | TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease. | ||||||||||||||||||||
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Adezmapimod hydrochloride | 99.86% | Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator. | ||||||||||||||||||||
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Adezmapimod (Standard) | 98.69% | Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator. | ||||||||||||||||||||
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L-167307 | L-167307 is an effective pyrrole-based p38 kinase inhibitor that can reduce secondary paw swelling in rat adjuvant-induced arthritis models. | |||||||||||||||||||||
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Ipriflavone metabolites IV | Ipriflavone metabolites IV is a metabolite of Ipriflavone (HY-N0094). | |||||||||||||||||||||
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2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole | 2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole is a laser dyes with high photoluminescence (PL) quantum efficiency. | |||||||||||||||||||||
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Formononetin | 99.21% | Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth. | ||||||||||||||||||||
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4',7-Dimethoxyisoflavone | 98.61% | 4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity. | ||||||||||||||||||||
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Isoformononetin (Standard) | ≥98% | Isoformononetin (Standard) is the analytical standard of Isoformononetin. This product is intended for research and analytical applications. Isoformononetin is an analog of Daidzein (HY-N0019) and has immunoprotective effects. Isoformononetin inhibits the differentiation of Th17 and B-cells lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. | ||||||||||||||||||||
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4,4'-(1,3,4-Oxadiazole-2,5-diyl)diphenol | 4,4'-(1,3,4-Oxadiazole-2,5-diyl)diphenol (2,5-Bis(4-hydroxyphenyl)-1,3,4-oxadiazole) is a metal-organic framework (MOF). | |||||||||||||||||||||
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Etoricoxib impurity 10 | Etoricoxib impurity 10 is an impurity of Etoricoxib (HY-15321). | |||||||||||||||||||||
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