1005501-84-7
1005501-84-7
Chemical Structure
D156844
- CAS No.: 1005501-84-7
- Formula:C21H24FN5O
- Molecular Weight:381.45
IUPAC Name: 5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
InChIKey: GYKIQIOWVKCVBP-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1
Biological Activity: D156844 (Compound 11a) is a SMN2 promoter activator with an EC50 of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research[1].
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D156844 | D156844 (Compound 11a) is a SMN2 promoter activator with an EC50 of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research. | |||||||||||||||||||||
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