1006877-41-3
1006877-41-3
Chemical Structure
Sifalimumab
Synonym(s): MEDI-545; MDX 1103
- CAS No.: 1006877-41-3
- Formula:N/A
- Molecular Weight:(144.24 kDa)
IUPAC Name: tert-butyl (3-bromo-5-cyanophenyl)carbamate
SMILES: [Sifalimumab]
Biological Activity: Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research[1][2].
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Sifalimumab | 99.46% | Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research. | ||||||||||||||||||||
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References
- [1]. Merrill JT, et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov;70(11):1905-13. [Content Brief]
- [2]. La Maestra S, et al. Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. Drug Deliv Transl Res. 2018 Oct;8(5):1345-1354. [Content Brief]
