10075-11-3
Chemical Structure
9(R)-HODE
Synonym(s): 9(R)-Hydroxyoctadecadienoic acid
- CAS No.: 10075-11-3
- Formula:C18H32O3
- Molecular Weight:296.44
IUPAC Name: (R,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
InChIKey: NPDSHTNEKLQQIJ-WXUVIADPSA-N
SMILES: CCCCC/C=C\C=C\[C@H](O)CCCCCCCC(O)=O
Biological Activity: 9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
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9(R)-HODE | 9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL. | |||||||||||||||||||||
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