100929-81-5
Chemical Structure
DL-Fluorocitric acid barium
- CAS No.: 100929-81-5
- Formula:C6H7FO7.3/2Ba
- Molecular Weight:416.10
SMILES: OC(CC(O)=O)(C(O)=O)C(F)C(O)=O.[1.5].[Ba]
Biological Activity: DL-Fluorocitric acid barium is a glial cell metabolic inhibitor. DL-Fluorocitric acid barium inhibits mechanical hyperalgesia induced by subcutaneous injection of complete Freund's adjuvant in rats. DL-Fluorocitric acid barium inhibits nociceptive behaviors induced by Histamine (HY-B1204) in mice and blocks the phosphorylation of the NMDA receptor NR1 subunit in the lumbar spinal cord of mice. DL-Fluorocitric acid (barium) can be used in the research of mechanical hyperalgesia and nociceptive pain[1][2].
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DL-Fluorocitric acid barium | DL-Fluorocitric acid barium is a glial cell metabolic inhibitor. DL-Fluorocitric acid barium inhibits mechanical hyperalgesia induced by subcutaneous injection of complete Freund's adjuvant in rats. DL-Fluorocitric acid barium inhibits nociceptive behaviors induced by Histamine (HY-B1204) in mice and blocks the phosphorylation of the NMDA receptor NR1 subunit in the lumbar spinal cord of mice. DL-Fluorocitric acid (barium) can be used in the research of mechanical hyperalgesia and nociceptive pain. | |||||||||||||||||||||
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References
- [1]. Zhang T, et al. Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity. Brain Res Bull. 2009;79(3-4):219-223. [Content Brief]
- [2]. Mizoguchi H, et al. Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. Eur J Pharmacol. 2011;653(1-3):21-25. [Content Brief]
