1009376-10-6
1009376-10-6
Chemical Structure
RTIL 13
- CAS No.: 1009376-10-6
- Formula:C30H55BrN2O3
- Molecular Weight:571.67
IUPAC Name: N-(2-((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-epoxyisoindol-2-yl)ethyl)-N,N-dimethyloctadecan-1-aminium bromide
InChIKey: NBQBCVMTAUPTCJ-PNXVFTDZSA-M
SMILES: O=C1[C@@]2([H])[C@](C(N1CC[N+](C)(C)CCCCCCCCCCCCCCCCCC)=O)([H])[C@H]3O[C@@H]2CC3.[Br-]
Biological Activity: RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[1][2].
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RTIL 13 | RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively. | |||||||||||||||||||||
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References
- [1]. Zhang J, et, al. From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry. 2008 Jan; 32(1): 1-180.
- [2]. Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle. Tuesday, December 28, 2021.
