1010100-22-7
1010100-22-7
Chemical Structure
Thalidomide-5-CH2-NH2 hydrochloride
- CAS No.: 1010100-22-7
- Formula:C14H14ClN3O4
- Molecular Weight:323.73
IUPAC Name: 5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
InChIKey: ODZXEQVQLJKSQH-UHFFFAOYSA-N
SMILES: NCC1=CC(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)=C3C=C1.Cl
Biological Activity: Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].
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Thalidomide-5-CH2-NH2 hydrochloride | 98.0% | Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs. | ||||||||||||||||||||
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Thalidomide-5-COOH | 99.94% | Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs. | ||||||||||||||||||||
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Thalidomide-4-C3-NH2 hydrochloride | Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. | |||||||||||||||||||||
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Thalidomide-5-propargyne-NH2 hydrochloride | 98.03% | Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. | ||||||||||||||||||||
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Thalidomide-5-methyl | 99.87% | Thalidomide-5-methyl is the Thalidomide (HY-14658)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide-5-methyl can be used to synthesize PROTAC. | ||||||||||||||||||||
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Thalidomide-CH2NH2 hydrochloride | 98.06% | Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions. | ||||||||||||||||||||
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5-Aminothalidomide | 99.51% | 5-Aminothalidomide is a cereblon E3 ligase ligand. 5-Aminothalidomide can be used to synthesize various PROTACs, such as PROTAC BRD9 Degrader-7 (HY-155361). | ||||||||||||||||||||
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Thalidomide-5-carbaldehyde | Thalidomide-5-carbaldehyde is a Thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions. | |||||||||||||||||||||
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5-Bromomethylthalidomide | 95.74% | 5-Bromomethylthalidomide is an E3 ligase activator which may be further derivatized by substitution at bromide. | ||||||||||||||||||||
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2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione | 98.66% | 2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog that can be useful in PROTAC research. | ||||||||||||||||||||
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Thalidomide-5-methanol | Thalidomide-5-methanol is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Thalidomide-5-methanol can be linked to a target protein ligand via a linker to form a PROTAC. | |||||||||||||||||||||
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