1016427-72-7
1016427-72-7
Chemical Structure
ERK2/p38α MAPK-IN-1
- CAS No.: 1016427-72-7
- Formula:C20H16FN3O4S2
- Molecular Weight:445.49
InChIKey: PCKXVDUIUFNAJD-UHFFFAOYSA-N
SMILES: COC1=C(OC)C=C(N=C(NC(C2=CSC(COC3=CC=C(F)C=C3)=N2)=O)S4)C4=C1
Biological Activity: ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes[1].
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ERK2/p38α MAPK-IN-1 | ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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