101708-64-9
101708-64-9
Chemical Structure
PD 116152
- CAS No.: 101708-64-9
- Formula:C16H12N2O6
- Molecular Weight:328.28
IUPAC Name: methyl 6-formyl-4,7,9-trihydroxy-8-methylphenazine-1-carboxylate
InChIKey: RZKNRCBVLASAPK-UHFFFAOYSA-N
SMILES: O=CC1=C(C(C)=C(C2=NC3=C(C(OC)=O)C=CC(O)=C3N=C21)O)O
Biological Activity: PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC50 values of 5.2 x 10-7 M and 7.1 x 10-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia[1][2].
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PD 116152 | PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC50 values of 5.2 x 10-7 M and 7.1 x 10-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia. | |||||||||||||||||||||
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References
- [1]. Smitka TA, et al. PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity. J Antibiot (Tokyo). 1986 Jun;39(6):800-3. [Content Brief]
- [2]. Tunac J B, et al. PD 116, 152, a novel phenazine antitumor antibiotic discovery, fermentation, culture characterization and biological activity[J]. The Journal of Antibiotics, 1986, 39(2): 192-197.
