1018983-66-8
Chemical Structure
α-Synuclein-IN-26
- CAS No.: 1018983-66-8
- Formula:C8H10N2O2
- Molecular Weight:166.18
IUPAC Name: 2-amino-5-hydroxy-N-methylbenzamide
InChIKey: LKOQKRDNICCKCZ-UHFFFAOYSA-N
SMILES: O=C(NC)C1=CC(O)=CC=C1N
Biological Activity: α-Synuclein-IN-26 is an α-Synuclein inhibitor that inhibits αSyn oligomerization (IC50 = 10.5 μM) and fibrillization, and binds to native monomeric αSyn. α-Synuclein-IN-26 has neuroprotective effects, protecting dopaminergic neurons from A53T αSyn-induced neurotoxicity. α-Synuclein-IN-26 does not affect intercellular transmission of αSyn and does not alter cellular αSyn protein levels, with no significant toxicity to dopaminergic neurons. α-Synuclein-IN-26 can be used in research related to Parkinson's disease[1].
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α-Synuclein-IN-26 | α-Synuclein-IN-26 is an α-Synuclein inhibitor that inhibits αSyn oligomerization (IC50 = 10.5 μM) and fibrillization, and binds to native monomeric αSyn. α-Synuclein-IN-26 has neuroprotective effects, protecting dopaminergic neurons from A53T αSyn-induced neurotoxicity. α-Synuclein-IN-26 does not affect intercellular transmission of αSyn and does not alter cellular αSyn protein levels, with no significant toxicity to dopaminergic neurons. α-Synuclein-IN-26 can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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