1020399-52-3
Chemical Structure
PRMT/HKMT-IN-1
- CAS No.: 1020399-52-3
- Formula:C19H12Br4O4
- Molecular Weight:623.92
IUPAC Name: 3,5-bis((E)-3,5-dibromo-4-hydroxybenzylidene)tetrahydro-4H-pyran-4-one
InChIKey: JEDNMNJCJIIYJR-NJDSBKIZSA-N
SMILES: O=C1C(=CC2=CC(Br)=C(O)C(Br)=C2)COCC1=CC3=CC(Br)=C(O)C(Br)=C3
Biological Activity: PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia[1].
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PRMT/HKMT-IN-1 | PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia. | |||||||||||||||||||||
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