1024168-48-6
Chemical Structure
Pantothenate kinase-IN-1
- CAS No.: 1024168-48-6
- Formula:C21H25N5O
- Molecular Weight:363.46
IUPAC Name: (1S,5S)-1-hydroxy-1-((2R,2'R,5R,5'R)-5'-((R)-1-hydroxy-13-((S)-5-methyl-2-oxo-2,5-dihydrofuran-3-yl)tridecyl)octahydro-[2,2'-bifuran]-5-yl)undecan-5-yl (tert-butoxycarbonyl)glycyl-L-prolinate
InChIKey: WPAWIBUDSFBBFI-UHFFFAOYSA-N
SMILES: CC(C)(C1=CC=C(C=C1)NC(N2CCN(CC2)C3=NC=C(C=C3)C#N)=O)C
Biological Activity: Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pantothenate kinase-IN-1 | 98.20% | Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases. | ||||||||||||||||||||
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