102601-60-5
102601-60-5
Chemical Structure
Co(III) protoporphyrin IX chloride
Synonym(s): Protoporphyrin IX cobaltic chloride; CoPPIX-Cl
- CAS No.: 102601-60-5
- Formula:C34H32ClCoN4O4
- Molecular Weight:655.03
InChIKey: WWNXKQFLDNSNDN-HXFTUNQESA-K
SMILES: O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC(O)=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Co+3]3([N-]78)([N-]54)[Cl-])O
Biological Activity: Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models[1][2][3][4].
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Co(III) protoporphyrin IX chloride | 95% | Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models. | ||||||||||||||||||||
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References
- [1]. Shan Y, et al. Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. FASEB J. 2006 Dec;20(14):2651-3. [Content Brief]
- [2]. Drummond GS, et al. The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci U S A. 1982 Apr;79(7):2384-8. [Content Brief]
- [3]. Li J, et al. Cobalt-protoporphyrin enhances heme oxygenase 1 expression and attenuates liver ischemia/reperfusion injury by inhibiting apoptosis. Mol Med Rep. 2018 Mar;17(3):4567-4572. [Content Brief]
- [4]. Willix JL, et al. Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01819-19. [Content Brief]
