1027630-05-2
Chemical Structure
WYRGRLC
- CAS No.: 1027630-05-2
- Formula:C43H64N14O9S
- Molecular Weight:953.12
InChIKey: CYAIFWUKJFRGHB-TZEHAJJTSA-N
SMILES: O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CNC3=CC=CC=C23)N
Biological Activity: WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis[1][2].
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WYRGRLC | WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis. | |||||||||||||||||||||
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References
- [1]. Rothenfluh DA, et al. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater. 2008;7(3):248-254. [Content Brief]
- [2]. Lin G, et al. Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system. Mater Today Bio. 2024;29:101279. Published 2024 Sep 28. [Content Brief]
