1030097-65-4
1030097-65-4
Chemical Structure
PAT1inh-A0030
- CAS No.: 1030097-65-4
- Formula:C17H18N4O3
- Molecular Weight:326.35
InChIKey: QTVIOFDSQRMUBD-UHFFFAOYSA-N
SMILES: O=C(C1=NC(N(CC2=CC=CC=C2)C)=C3C(ON=C3C)=N1)OCC
Biological Activity: PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC50= 1.0 μM). PAT1inh-A0030 inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption. PAT1inh-A0030 can be used in the study of intestinal diseases related to CF[1].
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PAT1inh-A0030 | PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC50= 1.0 μM). PAT1inh-A0030 inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption. PAT1inh-A0030 can be used in the study of intestinal diseases related to CF. | |||||||||||||||||||||
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