1030098-18-0
1030098-18-0
Chemical Structure
GPX4 activator 1
- CAS No.: 1030098-18-0
- Formula:C20H26N6O2S
- Molecular Weight:414.52
InChIKey: QKCIZEYOXJNTHO-UHFFFAOYSA-N
SMILES: CN(CC1)CCN1C2=NN=C(S2)N3C=CC=C3CNC4=CC=C(OC)C(OC)=C4
Biological Activity: GPX4 activator 1 is an allosteric activator of glutathione peroxidase 4 (GPX4) with a Kd value of 5.86 μM. GPX4 activator 1 binds to a specific region of GPX4 to alter protein binding kinetics and counteract ferroptosis (EC50 = 19.19 μM). GPX4 activator 1 inhibits lipid peroxidation, rescues ferroptotic cell death and maintains cell viability. GPX4 activator 1 can be used in studies related to Doxorubicin (HY-15142A)-induced myocardial injury[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GPX4 activator 1 | 99.02% | GPX4 activator 1 is an allosteric activator of glutathione peroxidase 4 (GPX4) with a Kd value of 5.86 μM. GPX4 activator 1 binds to a specific region of GPX4 to alter protein binding kinetics and counteract ferroptosis (EC50 = 19.19 μM). GPX4 activator 1 inhibits lipid peroxidation, rescues ferroptotic cell death and maintains cell viability. GPX4 activator 1 can be used in studies related to Doxorubicin (HY-15142A)-induced myocardial injury. | ||||||||||||||||||||
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