1030594-28-5
1030594-28-5
Chemical Structure
(+)-Arhalofenate
Synonym(s): (+)-MBX 102;(+)-JNJ 39659100
- CAS No.: 1030594-28-5
- Formula:C19H17ClF3NO4
- Molecular Weight:415.79
SMILES: O=C(OCCNC(C)=O)[C@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2
Biological Activity: (+)-Arhalofenate ((+)-MBX 102) is the less active enantiomer of Arhalofenate (HY-14831). Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(+)-Arhalofenate | 99.85% | (+)-Arhalofenate ((+)-MBX 102) is the less active enantiomer of Arhalofenate (HY-14831). Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. | ||||||||||||||||||||
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References
- [1]. Gregoire FM, et al. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23(7):975-88. [Content Brief]
- [2]. Chandalia A, et al. MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation. PPAR Res. 2009;2009:706852. [Content Brief]
- [3]. Kenneth L. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia. WO2000074666A2
