103379-02-8
Chemical Structure
Monatepil hydrochloride
Synonym(s): AJ-2615 hydrochloride
- CAS No.: 103379-02-8
- Formula:C28H31ClFN3OS
- Molecular Weight:512.08
InChIKey: SJLXYQPZWXMNNW-UHFFFAOYSA-N
SMILES: O=C(CCCN1CCN(CC1)C2=CC=C(C=C2)F)NC3C4=C(SCC5=C3C=CC=C5)C=CC=C4.Cl
Biological Activity: Monatepil (AJ-2615 free base) hydrochloride is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil hydrochloride inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil hydrochloride also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts. Monatepil hydrochloride can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina[1][2][3].
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Monatepil hydrochloride | Monatepil (AJ-2615 free base) hydrochloride is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil hydrochloride inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil hydrochloride also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts. Monatepil hydrochloride can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina. | |||||||||||||||||||||
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References
- [1]. Miyazaki M, et al. Antihypertensive, antiatherosclerotic, and plasma lipid-lowering effects of monatepil, a novel calcium antagonist with alpha 1-adrenoceptor-blocking activity in experimental animals. American journal of hypertension. 1994 Oct;7(10 Pt 2):131S-40S.
- [2]. Yamamoto T, et al. Preventive effect of a new calcium antagonist, monatepil, on drug-induced ischaemic electrocardiographic changes in rats. Clinical and experimental pharmacology & physiology. 1993 Nov;20(11):673-8.
- [3]. Sasaki J, et al. Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension. American journal of hypertension. 1994 Oct;7(10 Pt 2):161S-166S.
