1033931-92-8
Chemical Structure
NSC647889
- CAS No.: 1033931-92-8
- Formula:C33H48N4OS
- Molecular Weight:548.83
IUPAC Name: 1-((3S,8R,9S,10S,13S,14S,17S)-17-(dimethylamino)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-3-(2-phenyl-1-(thiazol-2-yl)ethyl)urea
InChIKey: QPOUCHIQTFZFLC-JNKAUUNZSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CCC1C[C@H](CC2)NC(NC(C4=NC=CS4)CC5=CC=CC=C5)=O)([H])[C@@]6([H])[C@](CC3)([C@H](CC6)N(C)C)C
Biological Activity: NSC647889 is an apoptosis and autophagy inducer. NSC647889 induces apoptosis, inhibits mTOR pathway and abrogates DNA synthesis. NSC647889 triggers LC3-positive vesicle formation, modulates AKT and 4EBP1 phosphorylation and shows heightened caspase-3 activation in multicellular spheroids. NSC647889 can be used for the research of solid cancer tumour, head-neck carcinoma, and colorectal cancer[1][2][3].
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NSC647889 | 99.28% | NSC647889 is an apoptosis and autophagy inducer. NSC647889 induces apoptosis, inhibits mTOR pathway and abrogates DNA synthesis. NSC647889 triggers LC3-positive vesicle formation, modulates AKT and 4EBP1 phosphorylation and shows heightened caspase-3 activation in multicellular spheroids. NSC647889 can be used for the research of solid cancer tumour, head-neck carcinoma, and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Linder S, et al. Treatment of solid tumours. France, WO2012128689 A. 2012-09-27.
- [2]. Mohanty C, et al. Massive induction of apoptosis of multicellular tumor spheroids by a novel compound with a calmodulin inhibitor-like mechanism. J. Cancer Res. Ther. 2013.
- [3]. Sensi F, et al. Preclinical three-dimensional colorectal cancer model: The next generation of in vitro drug efficacy evaluation. J Cell Physiol. 2018;234(1):181-191. [Content Brief]
