103412-40-4
Chemical Structure
B 4310
- CAS No.: 103412-40-4
- Formula:C62H95N19O14S2
- Molecular Weight:1394.68
IUPAC Name: ((S)-2-((R)-2-((S)-2-((S)-2-(2-((2S,4R)-1-(L-lysyl-L-lysyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanamido)-3-hydroxypropanamido)-3-phenylpropanamido)-3-(thiophen-2-yl)propanoyl)-L-arginine
InChIKey: BAPXVPGXAHEAKB-BYZYXFGASA-N
SMILES: C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(NCC(N[C@@H](CC3=CC=CS3)C(N[C@H](C(N[C@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=CS5)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)CO)=O)=O)=O)C[C@@H](O)C2
Biological Activity: B 4310 is a non-organ-selective Bradykinin antagonist. B 4310 induces uterine contraction in rats. B 4310 blocks bradykinin-mediated responses, including substance P release, plasma extravasation, venous contraction, prostaglandin E2 release and trigeminal nerve stimulation, but exerts no effect on angiotensin II, acetylcholine or capsaicin pathways. B 4310 exerts a reversible antagonistic effect on bradykinin-induced nociceptors. B 4310 serves as a tool for investigating the biological effects of bradykinin[1][2].
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B 4310 | B 4310 is a non-organ-selective Bradykinin antagonist. B 4310 induces uterine contraction in rats. B 4310 blocks bradykinin-mediated responses, including substance P release, plasma extravasation, venous contraction, prostaglandin E2 release and trigeminal nerve stimulation, but exerts no effect on angiotensin II, acetylcholine or capsaicin pathways. B 4310 exerts a reversible antagonistic effect on bradykinin-induced nociceptors. B 4310 serves as a tool for investigating the biological effects of bradykinin. | |||||||||||||||||||||
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References
- [1]. Griesbacher T, et al. Effects of the bradykinin antagonist B4310 on smooth muscles and blood pressure in the rat, and its enzymatic degradation. British journal of pharmacology. 1989 Mar;96(3):531-8. [Content Brief]
- [2]. Griesbacher T, et al. Effect of bradykinin antagonists on bradykinin-induced plasma extravasation, venoconstriction, prostaglandin E2 release, nociceptor stimulation and contraction of the iris sphincter muscle in the rabbit. British journal of pharmacology. 1987 Oct;92(2):333-40. [Content Brief]
