1034152-93-6
Chemical Structure
MK-7725
- CAS No.: 1034152-93-6
- Formula:C25H19F6N5O5S
- Molecular Weight:615.50
IUPAC Name: 2-(3-(6-((4-(trifluoromethoxy)phenyl)sulfonyl)-2-(trifluoromethyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-7-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol
InChIKey: WQQNCCUPGPFWOI-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C=C1)OC(F)(F)F)(N2C3=C(C4=NOC(C(C)(C)O)=N4)C=CC=C3NC5=NC(C(F)(F)F)=CC=C5C2)=O
Biological Activity: MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC50 of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC50 of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity[1].
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MK-7725 | MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC50 of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC50 of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity. | |||||||||||||||||||||
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