1034297-58-9
1034297-58-9
Chemical Structure
CRT5
Synonym(s): CRT0066051
- CAS No.: 1034297-58-9
- Formula:C28H30N4O2
- Molecular Weight:454.56
IUPAC Name: 3-(6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide
InChIKey: XBDRAUPLGHAFCU-UHFFFAOYSA-N
SMILES: O=C(NCCN(C)C)C1=CC=CC(C2=CC(C3=CC=C4C=C(OCC)C=CC4=C3)=C(N)N=C2)=C1
Biological Activity: CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CRT5 | 98.70% | CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis. | ||||||||||||||||||||
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