10387-49-2
Chemical Structure
7-Acetoxycoumarin
Synonym(s): Acetylumbelliferone
- CAS No.: 10387-49-2
- Formula:C11H8O4
- Molecular Weight:204.18
InChIKey: MGZOXZPZHVOXQB-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C=C1)C=CC(OC(C)=O)=C2
Biological Activity: 7-Acetoxycoumarin (Acetylumbelliferone) is an anti-inflammatory inhibitor with antibacterial and amoebicidal activities. 7-Acetoxycoumarin reduces the phosphorylation levels of ERK, JNK, NF-κB and p38 MAPK. 7-Acetoxycoumarin downregulates the protein and mRNA expression levels of iNOS and COX-2. 7-Acetoxycoumarin inhibits the production of IL-1β, IL-6, TNF-α, NO and PG2. 7-Acetoxycoumarin reduces the degradation of IκBα. 7-Acetoxycoumarin can be used in studies related to amoebiasis and Bacillus lentus infection[1][2][3][4].
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7-Acetoxycoumarin | 7-Acetoxycoumarin (Acetylumbelliferone) is an anti-inflammatory inhibitor with antibacterial and amoebicidal activities. 7-Acetoxycoumarin reduces the phosphorylation levels of ERK, JNK, NF-κB and p38 MAPK. 7-Acetoxycoumarin downregulates the protein and mRNA expression levels of iNOS and COX-2. 7-Acetoxycoumarin inhibits the production of IL-1β, IL-6, TNF-α, NO and PG2. 7-Acetoxycoumarin reduces the degradation of IκBα. 7-Acetoxycoumarin can be used in studies related to amoebiasis and Bacillus lentus infection. | |||||||||||||||||||||
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References
- [1]. Park T, et al. 7-Acetoxycoumarin Inhibits LPS-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophage Cells. Molecules (Basel, Switzerland). 2020 Jul 08;25(14):3124. [Content Brief]
- [2]. Deiana M, et al. Chemical composition and antioxidant activity of extracts from Daphne gnidium L. Journal of the American Oil Chemists' Society. 2003;80(1):65‑70.
- [3]. Iqbal PF, et al. Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives. European journal of medicinal chemistry. 2009 May;44(5):2252-9. [Content Brief]
- [4]. Cottiglia F, et al. Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2001 Jul;8(4):302-5. [Content Brief]
