104153-37-9
104153-37-9
Chemical Structure
Rilopirox
Synonym(s): HOE 351
- CAS No.: 104153-37-9
- Formula:C19H16ClNO4
- Molecular Weight:357.79
IUPAC Name: 6-((4-(4-chlorophenoxy)phenoxy)methyl)-1-hydroxy-4-methylpyridin-2(1H)-one
InChIKey: UDYUIWXQUBNDHC-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C=C(COC2=CC=C(OC3=CC=C(Cl)C=C3)C=C2)N1O
Biological Activity: Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research[1][2].
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Rilopirox | Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research. | |||||||||||||||||||||
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References
- [1]. R Kruse, et al. Studies for the elucidation of the mode of action of the antimycotic hydroxypyridone compound, rilopirox. Pharmacology. 1991;43(5):247-55. [Content Brief]
- [2]. P Nenoff, et al. In vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant Candida isolates from patients with HIV infection. Mycoses. 1999 Apr;42(1-2):55-60. [Content Brief]
