104162-47-2
104162-47-2
Chemical Structure
DODMA
- CAS No.: 104162-47-2
- Formula:C41H81NO2
- Molecular Weight:620.09
IUPAC Name: N,N-dimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-amine
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\CCCCCCCC)CN(C)C
Biological Activity: DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DODMA | 98.53% | DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery. | ||||||||||||||||||||
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1,2(R)-Dioleyloxy-3-dimethylamino-propane | 1,2(R)-Dioleyloxy-3-dimethylamino-propane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA (HY-112755). | |||||||||||||||||||||
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DLinDMA | 99.49% | DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery. | ||||||||||||||||||||
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DODAP | 99.65% | DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation. | ||||||||||||||||||||
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DOTMA | 99.91% | DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo. | ||||||||||||||||||||
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(R)-DOTMA | (R)-DOTMA is a cationic lipid that can be used to construct lipid nanoparticles and lipoplexes. (R)-DOTMA binds nucleic acid molecules such as mRNA through electrostatic interactions, facilitating nucleic acid encapsulation and cellular delivery. (R)-DOTMA can form lipid systems with DOPE (HY-112005) or cholesterol (HY-N0322). (R)-DOTMA is applicable to mRNA delivery, vaccine development, cancer immunotherapy and gene editing research. | |||||||||||||||||||||
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DODAP hydrochloride | DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery. | |||||||||||||||||||||
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1,3-Dioleylglycerylether | 1,3-Dioleylglycerylether is an ester product. | |||||||||||||||||||||
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DSDMA | DSDMA is an ionizable ether lipid for RNA and vaccine delivery. | |||||||||||||||||||||
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Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride | Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Dioleyldimethylammonium chloride | 95.88% | Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer. | ||||||||||||||||||||
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References
- [1]. Heyes J, Palmer L, Bremner K, MacLachlan I. Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. J Control Release. 2005;107(2):276-287. [Content Brief]
- [2]. Yu B, et al. Insight into mechanisms of cellular uptake of lipid nanoparticles and intracellular release of small RNAs. Pharm Res. 2014 Oct;31(10):2685-95. [Content Brief]
