104229-37-0
104229-37-0
Chemical Structure
PD 118717
- CAS No.: 104229-37-0
- Formula:C20H22N4O3
- Molecular Weight:366.41
IUPAC Name: 7-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propoxy)-2H-chromen-2-one
InChIKey: VOVJICPSVGGMIF-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC=C(OCCCN3CCN(C4=NC=CC=N4)CC3)C=C2O1
Biological Activity: PD 118717 is a selective dopamine (DA) D-2 autoreceptor agonist. PD 118717 has significant affinity for 5-HT1A but not 5-HT1B and 5-HT2 receptors. PD 118717 is active in antagonizing the tau-Butyrolactone-induced accumulation of dopa in rat striatum and mesolimbic regions. PD 118717 exhibits an antipsychotic-like profile[1].
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PD 118717 | PD 118717 is a selective dopamine (DA) D-2 autoreceptor agonist. PD 118717 has significant affinity for 5-HT1A but not 5-HT1B and 5-HT2 receptors. PD 118717 is active in antagonizing the tau-Butyrolactone-induced accumulation of dopa in rat striatum and mesolimbic regions. PD 118717 exhibits an antipsychotic-like profile. | |||||||||||||||||||||
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