1045857-53-1
1045857-53-1
Chemical Structure
XM462
- CAS No.: 1045857-53-1
- Formula:C25H51NO3S
- Molecular Weight:445.74
IUPAC Name: N-((2S,3S)-1,3-dihydroxy-4-(tridecylthio)butan-2-yl)octanamide
InChIKey: FOIBJHCOSKEGLA-BJKOFHAPSA-N
SMILES: CCCCCCCC(N[C@@H](CO)[C@H](O)CSCCCCCCCCCCCCC)=O
Biological Activity: XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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XM462 | 99.80% | XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor. | ||||||||||||||||||||
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C8-Ceramide | 98.0% | C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro. | ||||||||||||||||||||
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C10 Ceramide | 99.93% | C10 ceramide is an endogenous, bioactive sphingolipid, | ||||||||||||||||||||
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C8 L-threo ceramide (d18:1/8:0) | C8 L-threo ceramide (d18:1/8:0) (N-Octanoyl-L-threo-sphingosine) is an ester product. | |||||||||||||||||||||
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C8 Dihydroceramide | 99.77% | C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro. | ||||||||||||||||||||
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C6-Phytoceramide | C6-Phytoceramide is a cell-permeable analog of Phytoceramide. C6-Phytoceramide induces higher levels of apoptosis than C6-Ceramide (HY-19542) in neuroblastoma cells. | |||||||||||||||||||||
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C8 Phytoceramide (t18:0/8:0) | C8 Phytoceramide (t18:0/8:0) is a ceramide. | |||||||||||||||||||||
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C12-Dihydro-ceramide | C12-Dihydro-ceramide is an ester product. | |||||||||||||||||||||
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C8 D-threo Ceramide (d18:1/8:0) | C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA. | |||||||||||||||||||||
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C4 Dihydroceramide | C4 Dihydroceramide is a biochemical assay reagent. | |||||||||||||||||||||
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N-Hexanoyldihydrosphingosine | N-Hexanoyldihydrosphingosine (C6-dihydro-Ceramide (N-hexanoyl-)) is an ester product. | |||||||||||||||||||||
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References
- [1]. Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3(6):946-53. [Content Brief]
- [2]. Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20(10):3173-9. [Content Brief]
