1046859-34-0
Chemical Structure
PF-4942847
- CAS No.: 1046859-34-0
- Formula:C20H18Cl2F3N7O2
- Molecular Weight:516.31
IUPAC Name: 4-(2-(2-(1H-pyrazol-1-yl)ethoxy)-4,6-dichlorophenyl)-2-amino-N-(2,2,2-trifluoroethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
InChIKey: GVSHPPIHCUEEAH-UHFFFAOYSA-N
SMILES: O=C(NCC(F)(F)F)N1CC=2N=C(N=C(C=3C(Cl)=CC(Cl)=CC3OCCN4N=CC=C4)C2C1)N
Biological Activity: PF-4942847 is an orally active HSP90 inhibitor with an IC50 of approximately 50 nM. PF-4942847 induces apoptosis in osteosarcoma cells, increases the proportion of cells in the sub-G1 phase and PARP cleavage, reduces the expression of Akt, Erk, MYC, c-MET and STAT-3, and regulates HSP expression. PF-4942847 can be used in studies related to osteosarcoma and HSP90[1][2].
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PF-4942847 | PF-4942847 is an orally active HSP90 inhibitor with an IC50 of approximately 50 nM. PF-4942847 induces apoptosis in osteosarcoma cells, increases the proportion of cells in the sub-G1 phase and PARP cleavage, reduces the expression of Akt, Erk, MYC, c-MET and STAT-3, and regulates HSP expression. PF-4942847 can be used in studies related to osteosarcoma and HSP90. | |||||||||||||||||||||
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