1047670-51-8
Chemical Structure
ABD459
- CAS No.: 1047670-51-8
- Formula:C24H17BrCl2N2O2
- Molecular Weight:516.21
IUPAC Name: (5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)(4-methoxyphenyl)methanone
InChIKey: ZUDJJNLJDWKCNV-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C(C2=CC=C(Br)C=C2)=C1C)C3=CC=C(C=C3Cl)Cl)C4=CC=C(C=C4)OC
Biological Activity: ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders[1].
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ABD459 | ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders. | |||||||||||||||||||||
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