1048002-36-3
Chemical Structure
Inolitazone hydrochloride hydrate
Synonym(s): Efatutazone hydrochloride hydrate; CS-7017 hydrochloride hydrate; RS5444 hydrochloride hydrate
- CAS No.: 1048002-36-3
- Formula:C27H30Cl2N4O5S
- Molecular Weight:593.52
IUPAC Name: 5-(4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)thiazolidine-2,4-dione dihydrochloride hydrate
InChIKey: JMFBDJASOQDDGR-UHFFFAOYSA-N
SMILES: CC1=C(N)C(C)=CC(OC2=CC(N(C)C(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)=N5)=C5C=C2)=C1.O.Cl.Cl
Biological Activity: Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer[1][2].
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Inolitazone hydrochloride hydrate | Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer. | |||||||||||||||||||||
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References
- [1]. Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17. [Content Brief]
- [2]. Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44. [Content Brief]
