1048660-43-0
Chemical Structure
ROC-0929
- CAS No.: 1048660-43-0
- Formula:C30H31N3O6S
- Molecular Weight:561.65
IUPAC Name: 2-((3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-indol-4-yl)oxy)-N-(phenylsulfonyl)propanamide
InChIKey: REUKAAAAEHWGGM-UHFFFAOYSA-N
SMILES: O=C(C(N)=O)C1=C(CC(C)C)N(CC2=CC=CC=C2)C3=CC=CC(OC(C)C(NS(=O)(C4=CC=CC=C4)=O)=O)=C31
Biological Activity: ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases[1].
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ROC-0929 | 99.62% | ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases. | ||||||||||||||||||||
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