104874-86-4
Chemical Structure
(S)-Doxazosin
Synonym(s): (S)-UK 33274
- CAS No.: 104874-86-4
- Formula:C23H25N5O5
- Molecular Weight:451.48
InChIKey: RUZYUOTYCVRMRZ-FQEVSTJZSA-N
SMILES: O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@H]4OC5=CC=CC=C5OC4
Biological Activity: (S)-Doxazosin is a long-acting selective α1-adrenoceptor antagonist. (S)-Doxazosin exhibits antihypertensive activity through lowering total perioheral resistance by selective postsynaptic α1-blockade. (S)-Doxazosin reduces blood pressure in dog model with experimentally induced renal hypertension. (S)-Doxazosin can alleviate bladder outflow obstruction. (S)-Doxazosin can also be studied in mental health disorder-related research[1][2][3].
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(S)-Doxazosin | (S)-Doxazosin is a long-acting selective α1-adrenoceptor antagonist. (S)-Doxazosin exhibits antihypertensive activity through lowering total perioheral resistance by selective postsynaptic α1-blockade. (S)-Doxazosin reduces blood pressure in dog model with experimentally induced renal hypertension. (S)-Doxazosin can alleviate bladder outflow obstruction. (S)-Doxazosin can also be studied in mental health disorder-related research. | |||||||||||||||||||||
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References
- [1]. Fulton, B., et al., (1995). Doxazosin. An update of its clinical pharmacology and therapeutic applications in hypertension and benign prostatic hyperplasia. Drugs, 49(2), 295-320. [Content Brief]
- [2]. Young, R. A., & Brogden, R. N. (1988). Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. Drugs, 35(5), 525-541. [Content Brief]
- [3]. Christie S. Richardson, et al., (2025). Doxazosin for the treatment of mental health disorders: A scoping review. PLOS Mental Health.
