105026-50-4
Chemical Structure
Antibiotic MX 2
- CAS No.: 105026-50-4
- Formula:C30H35NO11
- Molecular Weight:585.61
IUPAC Name: 8-ethyl-1,6,7,8,11-pentahydroxy-10-((5-hydroxy-6-methyl-4-morpholinotetrahydro-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: OPBPMGYBSDKJBT-UHFFFAOYSA-N
SMILES: O=C1C=2C=CC=C(O)C2C(=O)C=3C(O)=C4C(=C(O)C13)C(O)C(O)(CC)CC4OC5OC(C)C(O)C(N6CCOCC6)C5
Biological Activity: Antibiotic MX 2 is an orally active antibiotic that can cross the blood-brain barrier. Antibiotic MX 2 inhibits the growth of drug-sensitive and multidrug-resistant tumor cells, prolongs the survival of tumor-bearing mice, induces single-strand and double-strand DNA breaks, suppresses colony formation of fresh human-derived tumor cells, and overcomes multidrug resistance mediated by P-glycoprotein. Antibiotic MX 2 can be used in research related to L1210 leukemia, Lewis lung cancer, colon adenocarcinoma type 26 and type 38, gastric adenocarcinoma, non-small cell lung cancer, mammary adenocarcinoma, drug-resistant P388 leukemia, renal cancer, melanoma, ovarian cancer, breast cancer, small cell lung cancer, and colorectal cancer[1][2].
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Antibiotic MX 2 | Antibiotic MX 2 is an orally active antibiotic that can cross the blood-brain barrier. Antibiotic MX 2 inhibits the growth of drug-sensitive and multidrug-resistant tumor cells, prolongs the survival of tumor-bearing mice, induces single-strand and double-strand DNA breaks, suppresses colony formation of fresh human-derived tumor cells, and overcomes multidrug resistance mediated by P-glycoprotein. Antibiotic MX 2 can be used in research related to L1210 leukemia, Lewis lung cancer, colon adenocarcinoma type 26 and type 38, gastric adenocarcinoma, non-small cell lung cancer, mammary adenocarcinoma, drug-resistant P388 leukemia, renal cancer, melanoma, ovarian cancer, breast cancer, small cell lung cancer, and colorectal cancer. | |||||||||||||||||||||
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References
- [1]. Watanabe M, et al. MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells. Cancer Res. 1988 Dec 1;48(23):6653-7. [Content Brief]
- [2]. Ebrahim el-Zayat AA, et al. Activity of the morpholino anthracycline 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2) against human tumor colony-forming units in vitro. Investigational new drugs. 1995;13(2):125-131. [Content Brief]
