105114-22-5
105114-22-5
Chemical Structure
K-252d
- CAS No.: 105114-22-5
- Formula:C26H23N3O5
- Molecular Weight:457.48
IUPAC Name: 13-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
InChIKey: FYQXRIMLEOPQQP-DDWDLLSFSA-N
SMILES: O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7
Biological Activity: K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
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K-252d | K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM). | |||||||||||||||||||||
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