1052076-77-3
1052076-77-3
Chemical Structure
Q94 hydrochloride
- CAS No.: 1052076-77-3
- Formula:C21H18Cl2N2
- Molecular Weight:369.29
IUPAC Name: 2-benzyl-1-(4-chlorobenzyl)-1H-benzo[d]imidazole hydrochloride
InChIKey: WXIWQTVPWYFEHP-UHFFFAOYSA-N
SMILES: ClC1=CC=C(CN2C3=CC=CC=C3N=C2CC4=CC=CC=C4)C=C1.Cl
Biological Activity: Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].
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Q94 hydrochloride | Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation. | |||||||||||||||||||||
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